Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

Mutations in the VHL tumor suppressor gene result in constitutive expression of many hypoxia-inducible genes, at least in part because of increases in the cellular level of hypoxia-inducible transcription factor HIF1α, which in normal cells is rapidly ubiquitinated and degraded by the proteasome und...

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Main Authors: Kamura, Takumi, Sato, Shigeo, Iwai, Kazuhiro, Czyzyk-Krzeska, Maria, Conaway, Ronald C., Conaway, Joan Weliky
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC27041/
https://ncbi.nlm.nih.gov/pubmed/10973499
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