Lithium Prevents and Ameliorates Experimental Autoimmune Encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE) models, in animals, many characteristics of multiple sclerosis, for which there is no adequate therapy. We investigated whether lithium, an inhibitor of glycogen synthase kinase-3 (GSK3), can ameliorate EAE in mice. Pretreatment with lithium markedly s...

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Hauptverfasser: De Sarno, Patrizia, Axtell, Robert C., Raman, Chander, Roth, Kevin A., Alessi, Dario R., Jope, Richard S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704026/
https://ncbi.nlm.nih.gov/pubmed/18566399
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