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A Single Intravenous Injection of Adeno-associated Virus Serotype-9 Leads to Whole Body Skeletal Muscle Transduction in Dogs

The success of many gene therapy applications hinges on efficient whole body transduction. In the case of muscular dystrophies, a therapeutic vector has to reach every muscle in the body. Recent studies suggest that vectors based on adeno-associated virus (AAV) are capable of body-wide transduction...

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Autors principals: Yue, Yongping, Ghosh, Arkasubhra, Long, Chun, Bostick, Brian, Smith, Bruce F, Kornegay, Joe N, Duan, Dongsheng
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703820/
https://ncbi.nlm.nih.gov/pubmed/18827804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.207
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