Elevated Glucocorticoid Levels Are Responsible for Induction of Tyrosine Hydroxylase mRNA Expression, Phosphorylation, and Enzyme Activity in the Nucleus of the Solitary Tract during Morphine Withdrawal

Chronic opiate exposure induces neurochemical adaptations in the noradrenergic system. Enhanced responsiveness of the hypothalamo-pituitary-adrenal axis after morphine withdrawal has been associated with hyperactivity of ascending noradrenergic input from the nucleus of the solitary tract (NTS-A(2))...

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Hauptverfasser: Núñez, Cristina, Földes, Anna, Pérez-Flores, Domingo, García-Borrón, J. Carlos, Laorden, M. Luisa, Kovács, Krisztina J., Milanés, M. Victoria
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Endocrine Society 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703550/
https://ncbi.nlm.nih.gov/pubmed/19179436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-1732
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