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Activation of PKR: An open and shut case?
The double-stranded (ds) RNA-activated protein kinase, PKR, plays a key role in the innate immunity response to viral infection in higher eukaryotes. PKR contains an N-terminal dsRNA binding domain and C-terminal kinase domain. In the prevalent autoinhibition model for PKR activation, dsRNA binding...
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| Hovedforfatter: | |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2703476/ https://ncbi.nlm.nih.gov/pubmed/17196820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2006.12.003 |
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