Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

The protein kinase Chk2, the mammalian homolog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases, is phosphorylated and activated in response to DNA damage by ionizing radiation (IR), UV irradiation, and replication blocks by hydroxyurea (HU). Phosphorylation and activation of Chk...

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Main Authors: Matsuoka, Shuhei, Rotman, Galit, Ogawa, Akira, Shiloh, Yosef, Tamai, Katsuyuki, Elledge, Stephen J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 2000
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC27034/
https://ncbi.nlm.nih.gov/pubmed/10973490
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