Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
The protein kinase Chk2, the mammalian homolog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases, is phosphorylated and activated in response to DNA damage by ionizing radiation (IR), UV irradiation, and replication blocks by hydroxyurea (HU). Phosphorylation and activation of Chk...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27034/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10973490/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.190030497 |
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