Targeting TNFα Rapidly Reduces Density of Dendritic Cells and Macrophages in Psoriatic Plaques with Restoration of Epidermal Keratinocyte Differentiation

BACKGROUND: The cytokine network theory for psoriasis postulates a key role for TNFa in mediating inflammation and altered epidermal differentiation. OBJECTIVE: This study defines responses following administration of adalimumab, a TNFα inhibitor, in pre-psoriatic skin (PN) and lesional psoriatic pl...

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Bibliographische Detailangaben
Hauptverfasser: Marble, Deborah J., Gordon, Kenneth B., Nickoloff, Brian J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2703191/
https://ncbi.nlm.nih.gov/pubmed/17689932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdermsci.2007.06.006
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