Molecular Mechanisms of HIF-1α Modulation Induced by Oxygen Tension and BMP2 in Glioblastoma Derived Cells

BACKGROUND: Glioblastoma multiforme (GBM) is one of most common and still poorly treated primary brain tumors. In search for new therapeutic approaches, Bone Morphogenetic Proteins (BMPs) induce astroglial commitment in GBM-derived cells in vitro. However, we recently suggested that hypoxia, which i...

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Autors principals: Pistollato, Francesca, Rampazzo, Elena, Abbadi, Sara, Della Puppa, Alessandro, Scienza, Renato, D'Avella, Domenico, Denaro, Luca, te Kronnie, Geertruy, Panchision, David M., Basso, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702690/
https://ncbi.nlm.nih.gov/pubmed/19587783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006206
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