BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression

Glioblastoma multiforme (GBM) is the most common brain tumour, characterized by a central and partially necrotic (i.e., hypoxic) core enriched in cancer stem cells (CSCs). We previously showed that the most hypoxic and immature (i.e., CSCs) GBM cells were resistant to Temozolomide (TMZ) in vitro, ow...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Persano, L, Pistollato, F, Rampazzo, E, Della Puppa, A, Abbadi, S, Frasson, C, Volpin, F, Indraccolo, S, Scienza, R, Basso, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481140/
https://ncbi.nlm.nih.gov/pubmed/23076220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.153
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados