BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression

Glioblastoma multiforme (GBM) is the most common brain tumour, characterized by a central and partially necrotic (i.e., hypoxic) core enriched in cancer stem cells (CSCs). We previously showed that the most hypoxic and immature (i.e., CSCs) GBM cells were resistant to Temozolomide (TMZ) in vitro, ow...

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Bibliografski detalji
Glavni autori: Persano, L, Pistollato, F, Rampazzo, E, Della Puppa, A, Abbadi, S, Frasson, C, Volpin, F, Indraccolo, S, Scienza, R, Basso, G
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481140/
https://ncbi.nlm.nih.gov/pubmed/23076220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.153
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