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Small Molecule Recognition of c-Src via the Imatinib-Binding Conformation
The cancer drug, Imatinib, is a selective Abl kinase inhibitor which does not inhibit the closely related kinase c-Src. This one drug and its ability to selectively inhibit Abl over c-Src has been a guiding principle in virtually all kinase drug discovery efforts in the last fifteen years. A promine...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2702663/ https://ncbi.nlm.nih.gov/pubmed/18940662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.09.007 |
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