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Amyloidogenic Processing but not AICD Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs

The β-amyloid peptide (Aβ) is the major constituent of the amyloid core of senile plaques found in the brain of patients with Alzheimer's disease (AD). Aβ is produced by the sequential cleavage of the Amyloid Precursor Protein (APP) by β- and γ-secretases. Cleavage of APP by γ-secretase also ge...

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Detaylı Bibliyografya
Asıl Yazarlar: Kienlen-Campard, Pascal, Tasiaux, Bernadette, Van Hees, Joanne, Li, Mingli, Huysseune, Sandra, Sato, Takeshi, Fei, Jeffrey Z., Aimoto, Saburo, Courtoy, Pierre J., Smith, Steven O., Constantinescu, Stefan N., Octave, Jean-Noël
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702479/
https://ncbi.nlm.nih.gov/pubmed/18201969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707142200
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