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Amyloidogenic Processing but not AICD Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs
The β-amyloid peptide (Aβ) is the major constituent of the amyloid core of senile plaques found in the brain of patients with Alzheimer's disease (AD). Aβ is produced by the sequential cleavage of the Amyloid Precursor Protein (APP) by β- and γ-secretases. Cleavage of APP by γ-secretase also ge...
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Główni autorzy: | , , , , , , , , , , , |
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Format: | Artigo |
Język: | Inglês |
Wydane: |
2008
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2702479/ https://ncbi.nlm.nih.gov/pubmed/18201969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707142200 |
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