Amyloidogenic Processing but not AICD Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs

समान संसाधन

• Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells
  द्वारा: Decock, Marie, और अन्य
  प्रकाशित: (2016)
• What is the role of amyloid precursor protein dimerization?
  द्वारा: Ben Khalifa, Naouel, और अन्य
  प्रकाशित: (2010)
• A helix-to-coil transition at the ε-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis
  द्वारा: Sato, Takeshi, और अन्य
  प्रकाशित: (2009)
• Presenilin Transmembrane Domain 8 Conserved AXXXAXXXG Motifs Are Required for the Activity of the γ-Secretase Complex
  द्वारा: Marinangeli, Claudia, और अन्य
  प्रकाशित: (2015)
• Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization
  द्वारा: Perrin, Florian, और अन्य
  प्रकाशित: (2020)