Amyloidogenic Processing but not AICD Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs

Eitemau Tebyg

• Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells
  gan: Decock, Marie, et al.
  Cyhoeddwyd: (2016)
• What is the role of amyloid precursor protein dimerization?
  gan: Ben Khalifa, Naouel, et al.
  Cyhoeddwyd: (2010)
• A helix-to-coil transition at the ε-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis
  gan: Sato, Takeshi, et al.
  Cyhoeddwyd: (2009)
• Presenilin Transmembrane Domain 8 Conserved AXXXAXXXG Motifs Are Required for the Activity of the γ-Secretase Complex
  gan: Marinangeli, Claudia, et al.
  Cyhoeddwyd: (2015)
• Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization
  gan: Perrin, Florian, et al.
  Cyhoeddwyd: (2020)