Neuroinflammation and Oxidation/Nitration of α-Synuclein Linked to Dopaminergic Neurodegeneration

α-Synuclein (SYN) is the major component of Lewy bodies, the neuropathological hallmarks of Parkinson's disease (PD). Missense mutations and multiplications of the SYN gene cause autosomal dominant inherited PD. Thus, SYN is implicated in the pathogenesis of PD. However, the mechanism whereby S...

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Bibliografiske detaljer
Main Authors: Gao, Hui-Ming, Kotzbauer, Paul T., Uryu, Kunihiro, Leight, Susan, Trojanowski, John Q., Lee, Virginia M.-Y.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2702093/
https://ncbi.nlm.nih.gov/pubmed/18650345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0143-07.2008
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