Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development

Notch signaling is vital for proper cardiovascular development and function in both humans and animal models. Indeed, mutations in either JAGGED or NOTCH cause congenital heart disease in humans and NOTCH mutations are associated with adult valvular disease. Notch typically functions to mediate deve...

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Autors principals: High, Frances A., Jain, Rajan, Stoller, Jason Z., Antonucci, Nicole B., Lu, Min Min, Loomes, Kathleen M., Kaestner, Klaus H., Pear, Warren S., Epstein, Jonathan A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701882/
https://ncbi.nlm.nih.gov/pubmed/19509466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38922
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