Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development

Notch signaling is vital for proper cardiovascular development and function in both humans and animal models. Indeed, mutations in either JAGGED or NOTCH cause congenital heart disease in humans and NOTCH mutations are associated with adult valvular disease. Notch typically functions to mediate deve...

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Bibliografische gegevens
Hoofdauteurs: High, Frances A., Jain, Rajan, Stoller, Jason Z., Antonucci, Nicole B., Lu, Min Min, Loomes, Kathleen M., Kaestner, Klaus H., Pear, Warren S., Epstein, Jonathan A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2009
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701882/
https://ncbi.nlm.nih.gov/pubmed/19509466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38922
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