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Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas
Pancreatic endocrine cells originate from precursors that express the transcription factor Neurogenin3 (Ngn3). Ngn3 expression is repressed by active Notch signaling. Accordingly, mice with Notch signaling pathway mutations display increased Ngn3 expression and endocrine cell lineage allocation. To...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2728177/ https://ncbi.nlm.nih.gov/pubmed/19501159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mod.2009.05.005 |
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