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Mutations of the GABA-A receptor α1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids
Neuroactive steroids are among the most efficacious modulators of the mammalian GABA-A receptor. Previous work has proposed that receptor potentiation is mediated by steroid interactions with a site defined by the residues α1N407/Y410 in the M4 transmembrane domain, and residue α1Q241 in the M1 doma...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701692/ https://ncbi.nlm.nih.gov/pubmed/18544665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.048520 |
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