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The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors

Oligophrenin-1 (OPHN1) encodes a Rho-GTPase-activating protein (Rho-GAP) whose loss of function has been associated with X-linked mental retardation (MR). The pathophysiological role of OPHN1, however, remains poorly understood. Here we show that OPHN1 through its Rho-GAP activity plays a critical r...

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Detalhes bibliográficos
Main Authors: Nadif Kasri, Nael, Nakano-Kobayashi, Akiko, Malinow, Roberto, Li, Bo, Van Aelst, Linda
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701582/
https://ncbi.nlm.nih.gov/pubmed/19487570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1783809
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