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Characterization of oligophrenin-1, a RhoGAP lost in patients affected with mental retardation. Lentiviral injection in organotypic brain slice cultures
Mutations in regulators and effectors of the Rho GTPases underlie various forms of mental retardation (MR). Among them, oligophrenin-1 (OPHN1), which encodes a Rho-GTPase activating protein (Rho-GAP), was one of the first Rho-linked MR gene identified. Upon characterization of OPHN1 in hippocampal b...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3556824/ https://ncbi.nlm.nih.gov/pubmed/18374170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0076-6879(07)00419-3 |
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