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Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity
The selective regulation of macroautophagy remains poorly defined. Here we report that PDGFR signaling is an essential selective promoter of hypoxia-induced macroautophagy. Hypoxia-induced macroautophagy in tumor cells is also HIF1α-dependent, with HIF1α integrating signals from PDGFRs and oxygen te...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701580/ https://ncbi.nlm.nih.gov/pubmed/19487569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.521709 |
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