ADAR1 is essential for maintenance of hematopoiesis and suppression of interferon signaling

ADAR1 (adenosine deaminase acting on RNA-1) edits adenosines in nuclear transcripts of nervous tissue and is also required at the fetal liver stage of the developing mouse embryo. Here we show by inducible gene disruption in mice that ADAR1 was essential for maintenance of both fetal and adult hemat...

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Bibliographic Details
Main Authors: Hartner, Jochen C., Walkley, Carl R., Lu, Jun, Orkin, Stuart H.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701568/
https://ncbi.nlm.nih.gov/pubmed/19060901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1680
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