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Contribution of the transmembrane domain 6 of melanocortin-4 receptor to peptide [Pro(5), DNaI (2′)(8)]-γ-MSH selectivity
The melanocortin receptor (MCR) subtype family is a member of the GPCR superfamily and each of them has a different pharmacological profile regarding the relative potency of the endogenous and synthetic melanocortin peptides. Substitution of Trp with DNaI (2′) in -γ-MSH resulted in the loss of bindi...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701352/ https://ncbi.nlm.nih.gov/pubmed/18930713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.09.023 |
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