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Renal injury is a third hit promoting rapid development of adult polycystic kidney disease
The ‘two-hit’ model is a widely accepted genetic mechanism for progressive cyst formation in autosomal dominant polycystic kidney disease. We have previously shown that adult inactivation of Pkd1 using the Mx1Cre(+) allele causes a late onset of focal cystic disease. An explanation for the delayed a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701325/ https://ncbi.nlm.nih.gov/pubmed/19342421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp147 |
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