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Antibodies in a heavy chain knock-in mouse exhibit characteristics of early heavy chain rearrangement

Studies in autoantibody transgenic mice have demonstrated receptor editing rearrangements at antibody heavy and light chain loci. However, the physiologic role of heavy chain editing (V(H) replacement and rearrangement on the second allele) has been called into question. It is unclear if additional...

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Bibliografske podrobnosti
Main Authors: Yunk, Lenka, Meng, Wenzhao, Cohen, Philip L., Eisenberg, Robert A., Luning Prak, Eline T.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700953/
https://ncbi.nlm.nih.gov/pubmed/19542457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804060
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