Structure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approach

Phospholamban (PLN) is an essential regulator of cardiac muscle contractility. The homopentameric assembly of PLN is the reservoir for active monomers that, upon deoligomerization form 1:1 complexes with the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA), thus modulating the rate of calcium upta...

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Hlavní autoři: Traaseth, Nathaniel J., Shi, Lei, Verardi, Raffaello, Mullen, Daniel G., Barany, George, Veglia, Gianluigi
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700893/
https://ncbi.nlm.nih.gov/pubmed/19509339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904290106
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