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Direct single-molecule observation of a protein living in two opposed native structures
Biological activity in proteins requires them to share the energy landscape for folding and global conformational motions, 2 key determinants of function. Although most structural studies to date have focused on fluctuations around a single structural basin, we directly observe the coexistence of 2...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2700882/ https://ncbi.nlm.nih.gov/pubmed/19506258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904461106 |
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