Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCγ1 activation for self-renewal of adult neural stem cells

BACKGROUND: Neural stem cells (NSCs) are present in the adult mammalian brain and sustain life-long adult neurogenesis in the dentate gyrus of the hippocampus. In culture, fibroblast growth factor-2 (FGF-2) is sufficient to maintain the self-renewal of adult NSCs derived from the adult rat hippocamp...

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Autors principals: Ma, Dengke K, Ponnusamy, Karthikeyan, Song, Mi-Ryoung, Ming, Guo-li, Song, Hongjun
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700800/
https://ncbi.nlm.nih.gov/pubmed/19505325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-2-16
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