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Bovine adenoviral vector-based H5N1 influenza vaccine overcomes exceptionally high levels of pre-existing immunity against human adenovirus
Because of high prevalence of adenovirus (Ad) infections in humans, it is believed that preexisting Ad-neutralizing antibodies (‘vector immunity’) may negatively impact the immune response to vaccine antigens when delivered by human Ad (HAd) vectors. In order to evaluate whether bovine adenovirus su...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2700267/ https://ncbi.nlm.nih.gov/pubmed/18301400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.12 |
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