Impact of Preexisting Adenovirus Vector Immunity on Immunogenicity and Protection Conferred with an Adenovirus-Based H5N1 Influenza Vaccine

The prevalence of preexisting immunity to adenoviruses in the majority of the human population might adversely impact the development of adaptive immune responses against adenovirus vector-based vaccines. To address this issue, we primed BALB/c mice either intranasally (i.n.) or intramuscularly (i.m...

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Detalhes bibliográficos
Main Authors: Pandey, Aseem, Singh, Neetu, Vemula, Sai V., Couëtil, Laurent, Katz, Jacqueline M., Donis, Ruben, Sambhara, Suryaprakash, Mittal, Suresh K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303828/
https://ncbi.nlm.nih.gov/pubmed/22432020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033428
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