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Molecular pharmacodynamics of PM02734 (elisidepsin) as single agent and in combination with erlotinib; synergistic activity in human non-small cell lung cancer cell lines and xenograft models
PM02734 (elisidepsin) is a novel marine-derived cyclic peptide belonging to the Kahaladide family of compounds currently under phase I development with early evidence of a positive therapeutic index. The cytotoxicity of PM02734 has been determined in a panel of human NSCLC (non-small cell lung cance...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2700178/ https://ncbi.nlm.nih.gov/pubmed/19346126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2009.03.003 |
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