A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential

Ion-channel function is determined by its gating movement. Yet, molecular dynamics and electrophysiological simulations were never combined to link molecular structure to function. We performed multiscale molecular dynamics and continuum electrostatics calculations to simulate a cardiac K(+) channel...

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Autori principali: Silva, Jonathan R., Pan, Hua, Wu, Dick, Nekouzadeh, Ali, Decker, Keith F., Cui, Jianmin, Baker, Nathan A., Sept, David, Rudy, Yoram
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700153/
https://ncbi.nlm.nih.gov/pubmed/19549851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904505106
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