SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

Hepatic gluconeogenesis is a major contributing factor to hyperglycemia in the fasting and postprandial states in type 2 diabetes mellitus (T2DM). Because Sirtuin 1 (SirT1) induces hepatic gluconeogenesis during fasting through the induction of phosphoenolpyruvate carboxylase kinase (PEPCK), fructos...

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Autors principals: Erion, Derek M., Yonemitsu, Shin, Nie, Yongzhan, Nagai, Yoshio, Gillum, Matthew P., Hsiao, Jennifer J., Iwasaki, Takanori, Stark, Romana, Weismann, Dirk, Yu, Xing Xian, Murray, Susan F., Bhanot, Sanjay, Monia, Brett P., Horvath, Tamas L., Gao, Qian, Samuel, Varman T., Shulman, Gerald I.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700142/
https://ncbi.nlm.nih.gov/pubmed/19549853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812931106
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