SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

Hepatic gluconeogenesis is a major contributing factor to hyperglycemia in the fasting and postprandial states in type 2 diabetes mellitus (T2DM). Because Sirtuin 1 (SirT1) induces hepatic gluconeogenesis during fasting through the induction of phosphoenolpyruvate carboxylase kinase (PEPCK), fructos...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Erion, Derek M., Yonemitsu, Shin, Nie, Yongzhan, Nagai, Yoshio, Gillum, Matthew P., Hsiao, Jennifer J., Iwasaki, Takanori, Stark, Romana, Weismann, Dirk, Yu, Xing Xian, Murray, Susan F., Bhanot, Sanjay, Monia, Brett P., Horvath, Tamas L., Gao, Qian, Samuel, Varman T., Shulman, Gerald I.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700142/
https://ncbi.nlm.nih.gov/pubmed/19549853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812931106
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares