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EGFR plays a pivotal role in the regulation of polyamine dependent apoptosis In intestinal epithelial cells

Intracellular polyamine synthesis is regulated by the enzyme ornithine decarboxylase (ODC), and its inhibition by α-difluromethylornithine (DFMO), confers resistance to apoptosis. We have previously shown that DFMO leads to the inhibition of de novo polyamine synthesis, which in turn rapidly activat...

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Библиографические подробности
Главные авторы: Ray, Ramesh M., Bhattacharya, Sujoy, Johnson, Leonard R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699668/
https://ncbi.nlm.nih.gov/pubmed/17825525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2007.08.001
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