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EGFR plays a pivotal role in the regulation of polyamine dependent apoptosis In intestinal epithelial cells
Intracellular polyamine synthesis is regulated by the enzyme ornithine decarboxylase (ODC), and its inhibition by α-difluromethylornithine (DFMO), confers resistance to apoptosis. We have previously shown that DFMO leads to the inhibition of de novo polyamine synthesis, which in turn rapidly activat...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699668/ https://ncbi.nlm.nih.gov/pubmed/17825525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2007.08.001 |
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