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Activation of Dbl restores migration in polyamine-depleted intestinal epithelial cells via Rho-GTPases

Integrin binding to the extracellular matrix (ECM) activated Rho GTPases, Src, and focal adhesion kinase in intestinal epithelial cells (IEC)-6. Polyamine depletion inhibited activities of Rac1, RhoA, and Cdc42 and thereby migration. However, constitutively active (CA) Rac1 expression abolished the...

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Bibliographic Details
Main Authors: Ray, Ramesh M., Bavaria, Mitulkumar N., Bhattacharya, Sujoy, Johnson, Leonard R.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119111/
https://ncbi.nlm.nih.gov/pubmed/21372162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00409.2010
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