Formalin-induced behavioural hypersensitivity and neuronal hyperexcitability are mediated by rapid protein synthesis at the spinal level

BACKGROUND: The mammalian target of rapamycin (mTOR) is a key regulator of mRNA translation whose action can be inhibited by the drug rapamycin. Forms of long-term plasticity require protein synthesis and evidence indicates that mRNA in dendrites, axon terminals and cell bodies is essential for long...

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Autores principales: Asante, Curtis O, Wallace, Victoria C, Dickenson, Anthony H
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699332/
https://ncbi.nlm.nih.gov/pubmed/19500426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-5-27
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