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TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks
TopBP1 and the Rad9–Rad1–Hus1 (9-1-1) complex activate the ataxia telangiectasia mutated and Rad3-related (ATR) protein kinase at stalled replication forks. ATR is recruited to stalled forks through its binding partner, ATR-interacting protein (ATRIP); however, it is unclear how TopBP1 and 9-1-1 are...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699152/ https://ncbi.nlm.nih.gov/pubmed/19289795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200810185 |
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