Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

Prostaglandins, particularly prostaglandin E2 (PGE2), play an important role during inflammation. This is exemplified by the clinical use of cyclooxygenase 2 inhibitors, which interfere with PGE2 synthesis, as effective antiinflammatory drugs. Here, we show that PGE2 directly promotes differentiatio...

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Autori principali: Boniface, Katia, Bak-Jensen, Kristian S., Li, Ying, Blumenschein, Wendy M., McGeachy, Mandy J., McClanahan, Terrill K., McKenzie, Brent S., Kastelein, Robert A., Cua, Daniel J., de Waal Malefyt, René
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699124/
https://ncbi.nlm.nih.gov/pubmed/19273625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082293
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