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A Novel Presynaptic Giant Ankyrin Stabilizes the NMJ through Regulation of Presynaptic Microtubules and Trans-Synaptic Cell Adhesion
In a forward genetic screen for mutations that destabilize the neuromuscular junction we identified a novel long isoform of Drosophila ankyrin2 (ank2-L). We demonstrate that loss of presynaptic Ank2-L not only causes synapse disassembly and retraction but also disrupts neuronal excitability and NMJ...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699047/ https://ncbi.nlm.nih.gov/pubmed/18439405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.02.017 |
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