A Novel Presynaptic Giant Ankyrin Stabilizes the NMJ through Regulation of Presynaptic Microtubules and Trans-Synaptic Cell Adhesion

In a forward genetic screen for mutations that destabilize the neuromuscular junction we identified a novel long isoform of Drosophila ankyrin2 (ank2-L). We demonstrate that loss of presynaptic Ank2-L not only causes synapse disassembly and retraction but also disrupts neuronal excitability and NMJ...

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Hlavní autoři: Pielage, Jan, Cheng, Ling, Fetter, Richard D., Carlton, Pete M., Sedat, John W., Davis, Graeme W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699047/
https://ncbi.nlm.nih.gov/pubmed/18439405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.02.017
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