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Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton

Loss of spectrin or ankyrin in the presynaptic motoneuron disrupts the synaptic microtubule cytoskeleton and leads to disassembly of the neuromuscular junction (NMJ). Here, we demonstrate that NMJ disassembly after loss of α-spectrin can be suppressed by expression of a Wld(S) transgene, providing e...

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Autors principals: Massaro, Catherine M., Pielage, Jan, Davis, Graeme W.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762090/
https://ncbi.nlm.nih.gov/pubmed/19805631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200903166
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