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BIM Regulates Apoptosis During Mammary Ductal Morphogenesis and its Absence Reveals Alternative Cell Death Mechanisms

The adult virgin mammary gland is a highly organized tree-like structure formed by ducts with hollowed lumen. Although lumen formation during pubertal development appears to involve apoptosis, the molecular mechanisms that regulate this process are not known. Here we demonstrate that disruption of t...

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Autori principali: Mailleux, Arnaud A., Overholtzer, Michael, Schmelzle, Tobias, Bouillet, Philippe, Strasser, Andrs, Brugge, Joan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698712/
https://ncbi.nlm.nih.gov/pubmed/17276340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2006.12.003
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