Directed Discovery of Agents Targeting the Met Tyrosine Kinase Domain by Virtual Screening

Hepatocyte growth factor (HGF) is an important regulator of normal development and homeostasis, and dysregulated signaling through the HGF receptor, Met, contributes to tumorigenesis, tumor progression and metastasis in numerous human malignancies. The development of selective small-molecule inhibit...

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Main Authors: Peach, Megan L., Tan, Nelly, Choyke, Sarah J., Giubellino, Alessio, Athauda, Gagani, Burke, Terrence R., Nicklaus, Marc C., Bottaro, Donald P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698034/
https://ncbi.nlm.nih.gov/pubmed/19199650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800791f
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