Selectivity and Mechanism of Action of a Growth Factor Receptor-Bound Protein 2 Src Homology 2 Domain Binding Antagonist

We have shown previously that a potent synthetic antagonist of Grb2 SH2 domain binding (1) blocks growth factor stimulated motility, invasion, and angiogenesis in cultured cell models, as well as tumor metastasis in animals. To characterize the selectivity of 1 for the SH2 domain of Grb2 over other...

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Detalhes bibliográficos
Main Authors: Giubellino, Alessio, Shi, Zhen-Dan, Miller Jenkins, Lisa M., Worthy, Karen M., Bindu, Lakshman K., Athauda, Gagani, Peruzzi, Benedetta, Fisher, Robert J., Appella, Ettore, Burke, Terrence R., Bottaro, Donald P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651228/
https://ncbi.nlm.nih.gov/pubmed/18989951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800523u
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