Učitavanje...
Selectivity and Mechanism of Action of a Growth Factor Receptor-Bound Protein 2 Src Homology 2 Domain Binding Antagonist
We have shown previously that a potent synthetic antagonist of Grb2 SH2 domain binding (1) blocks growth factor stimulated motility, invasion, and angiogenesis in cultured cell models, as well as tumor metastasis in animals. To characterize the selectivity of 1 for the SH2 domain of Grb2 over other...
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| Glavni autori: | , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2651228/ https://ncbi.nlm.nih.gov/pubmed/18989951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800523u |
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