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Directed Discovery of Agents Targeting the Met Tyrosine Kinase Domain by Virtual Screening
Hepatocyte growth factor (HGF) is an important regulator of normal development and homeostasis, and dysregulated signaling through the HGF receptor, Met, contributes to tumorigenesis, tumor progression and metastasis in numerous human malignancies. The development of selective small-molecule inhibit...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2698034/ https://ncbi.nlm.nih.gov/pubmed/19199650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800791f |
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