Endogenous IGF-I and α(v)β(3) integrin ligands regulate increased smooth muscle growth in TNBS-induced colitis

Endogenous insulin-like growth factor-I (IGF-I) regulates intestinal smooth muscle growth by concomitantly stimulating proliferation and inhibiting apoptosis. IGF-I-stimulated growth is augmented by the α(v)β(3) integrin ligands vitronectin and fibronectin. IGF-I expression in smooth muscle is incre...

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Bibliographic Details
Main Authors: Hazelgrove, Krystina B., Flynn, Robert S., Qiao, Li-Ya, Grider, John R., Kuemmerle, John F.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2009
Subjects:
Inflammation/Immunity/Mediators
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697946/
https://ncbi.nlm.nih.gov/pubmed/19359426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90508.2008
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