Use of the H(3) receptor antagonist radioligand [(3)H]-A-349821 to reveal in vivo receptor occupancy of cognition enhancing H(3) receptor antagonists

BACKGROUND AND PURPOSE: The histamine H(3) receptor antagonist radioligand [(3)H]-A-349821 was characterized as a radiotracer for assessing in vivo receptor occupancy by H(3) receptor antagonists that affect behaviour. This model was established as an alternative to ex vivo binding methods, for rela...

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Main Authors: Miller, TR, Milicic, I, Bauch, J, Du, J, Surber, B, Browman, KE, Marsh, K, Cowart, M, Brioni, JD, Esbenshade, TA
格式: Artigo
語言:Inglês
出版: Blackwell Publishing Ltd 2009
主題:
Research Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697797/
https://ncbi.nlm.nih.gov/pubmed/19413577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00239.x
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