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Inotropy and L-type Ca(2+) current, activated by β(1)- and β(2)-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart
BACKGROUND AND PURPOSE: β(1)- and β(2)-adrenoceptors coexist in rat heart but β(2)-adrenoceptor-mediated inotropic effects are hardly detectable, possibly due to phosphodiesterase (PDE) activity. We investigated the influence of the PDE3 inhibitor cilostamide (300 nmol·L(−1)) and the PDE4 inhibitor...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Blackwell Publishing Ltd
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2697770/ https://ncbi.nlm.nih.gov/pubmed/19133992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2008.00015.x |
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